Critical appraisal on journal of clinical trials.

Critical appraisal is an element of evidence-based medicine, which is defined as the process of carefully and systematically examining a research article to determine its reliability, validity and value in clinical practice. The major components evaluated in critical appraisal are validity, importancy, and applicability. The level of reliability of study results depend on the design of study, in which clinical trial has the highest rank. Critical appraisal includes all components of the research starting from the introduction, method, results and discussion. Each component has similar value to establish whether the results can realistically be applied as a reference. The results of statistical significance should also been compared with its clinical significance.